Functionalized nanofibers for prevention of incisional hernia formation

Project ID: 17-322851A
Funding provider: AZV ČR
Investigator at UCEEB: RNDr. Jan Sabó CSc.
Project duration: 1. 4. 2017 – 31. 12. 2021
Partner: Univerzita Karlova v Praze, 2LF, Veterinární a farmaceutická univerzita Brno

The incisional hernia is one of the most frequent complications affecting around 20% of all laparotomies. Around half of them suffer a recurrence when operated and one forth when surgical mesh is used. Unfortunately, even the surgical mesh can cause a wide range of complications and poses a lifelong risk for the patient. The biological mesh has brought a certain change to this concept. However, due to its biological origin this material triggers an immunological response of the organism and its manufacturing is extremely expensive. The biodegradable polycaprolactone nanofibres mimicking the extracellular matrix with their 3D structure could become an alternative as they are biocompatible and support fibroplasia. They have been tested as a material suitable for abdominal wall reconstruction already. Nanofibres will be further functionalized with platelet derivatives as a source of natural growth factors. Final samples will be tested on small animal model (rabbit).